Compile Data Set for Download or QSAR

Found 3 hits Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase JAK2' and Ligand = 'BDBM127738'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM127738 (US10251889, Example 111 | US10758542, Example 111 ...) Show SMILES CC(C)(O)CNC(=O)c1cnn2ccc(nc12)N1CCCC1c1cncc(F)c1 Show InChI InChI=1S/C20H23FN6O2/c1-20(2,29)12-23-19(28)15-11-24-27-7-5-17(25-18(15)27)26-6-3-4-16(26)13-8-14(21)10-22-9-13/h5,7-11,16,29H,3-4,6,12H2,1-2H3,(H,23,28)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	37.8	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2R49T22
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM127738 (US10251889, Example 111 | US10758542, Example 111 ...) Show SMILES CC(C)(O)CNC(=O)c1cnn2ccc(nc12)N1CCCC1c1cncc(F)c1 Show InChI InChI=1S/C20H23FN6O2/c1-20(2,29)12-23-19(28)15-11-24-27-7-5-17(25-18(15)27)26-6-3-4-16(26)13-8-14(21)10-22-9-13/h5,7-11,16,29H,3-4,6,12H2,1-2H3,(H,23,28)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Array Biopharma, Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US8791123 (2014) BindingDB Entry DOI: 10.7270/Q2Q23XX7
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM127738 (US10251889, Example 111 | US10758542, Example 111 ...) Show SMILES CC(C)(O)CNC(=O)c1cnn2ccc(nc12)N1CCCC1c1cncc(F)c1 Show InChI InChI=1S/C20H23FN6O2/c1-20(2,29)12-23-19(28)15-11-24-27-7-5-17(25-18(15)27)26-6-3-4-16(26)13-8-14(21)10-22-9-13/h5,7-11,16,29H,3-4,6,12H2,1-2H3,(H,23,28)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...				US Patent US9782415 (2017) BindingDB Entry DOI: 10.7270/Q2P84F0G
					More data for this Ligand-Target Pair