Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase JAK2' and Ligand = 'BDBM130291'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM130291 (US8815840, 197) Show SMILES COc1ccc(cc1F)-c1cc(C(N)=O)c2[nH]c3ccc(cc3c2c1)C(=O)N1CCC(O)CC1 Show InChI InChI=1S/C26H24FN3O4/c1-34-23-5-3-14(13-21(23)27)16-11-19-18-10-15(26(33)30-8-6-17(31)7-9-30)2-4-22(18)29-24(19)20(12-16)25(28)32/h2-5,10-13,17,29,31H,6-9H2,1H3,(H2,28,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	7.4	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The assays were performed in V-bottom 384-well plates. The final assay volume was 30 ul prepared from 15 ul additions of enzyme and substrates (fluor...				US Patent US8815840 (2014) BindingDB Entry DOI: 10.7270/Q28P5Z65
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