Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase JAK2' and Ligand = 'BDBM130295'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM130295 (US8815840, 211) Show SMILES COc1ccc(cc1F)-c1nc(C(N)=O)c2[nH]c3cc(ccc3c2n1)C(=O)N1CCC(C1)N(C)C Show InChI InChI=1S/C25H25FN6O3/c1-31(2)15-8-9-32(12-15)25(34)14-4-6-16-18(11-14)28-21-20(16)29-24(30-22(21)23(27)33)13-5-7-19(35-3)17(26)10-13/h4-7,10-11,15,28H,8-9,12H2,1-3H3,(H2,27,33)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	7.4	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The assays were performed in V-bottom 384-well plates. The final assay volume was 30 ul prepared from 15 ul additions of enzyme and substrates (fluor...				US Patent US8815840 (2014) BindingDB Entry DOI: 10.7270/Q28P5Z65
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