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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase JAK2' and Ligand = 'BDBM366969'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM366969
PNG
(4,4,4-trifluoro-1-[4-[2- [4-[2-(2- pyridylmethyl) ...)
Show SMILES FC(F)(F)CCC(=O)N1CCC(=CC1)c1cccn2nc(Nc3ccc(cc3)C(=O)N3CCCCC3Cc3ccccn3)nc12 |c:11|
Show InChI InChI=1S/C33H34F3N7O2/c34-33(35,36)16-13-29(44)41-20-14-23(15-21-41)28-8-5-19-43-30(28)39-32(40-43)38-25-11-9-24(10-12-25)31(45)42-18-4-2-7-27(42)22-26-6-1-3-17-37-26/h1,3,5-6,8-12,14,17,19,27H,2,4,7,13,15-16,18,20-22H2,(H,38,40)
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US Patent
 0.260n/an/an/an/an/an/an/an/a



Duquesne University



Assay Description
The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...

J Med Chem 51: 68-76 (2008)


BindingDB Entry DOI: 10.7270/Q2CC130F
More data for this
Ligand-Target Pair