Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase JAK2' and Ligand = 'BDBM50135120'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50135120 (CHEMBL3746486) Show SMILES CNc1c(Cl)cnc2[nH]c(nc12)-c1ccc(OC)cc1 Show InChI InChI=1S/C14H13ClN4O/c1-16-11-10(15)7-17-14-12(11)18-13(19-14)8-3-5-9(20-2)6-4-8/h3-7H,1-2H3,(H2,16,17,18,19)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of N-terminal GST-fused recombinant JAK2 (831 to 1132 residues) (unknown origin) expressed in insect cells using 5FAM-GEEPLYWSFPAKKK-NH2 a...				Bioorg Med Chem Lett 26: 60-7 (2015) Article DOI: 10.1016/j.bmcl.2015.11.031 BindingDB Entry DOI: 10.7270/Q2Z60QWQ
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