Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase JAK2' and Ligand = 'BDBM50393746'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50393746 (CHEMBL2159209) Show SMILES Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](O)CC1 |r,wU:16.19,wD:13.15,(24.47,-17.1,;25.29,-18.4,;24.72,-19.83,;25.91,-20.81,;25.96,-22.35,;27.33,-23.07,;28.63,-22.24,;30.11,-22.66,;30.96,-21.38,;30.01,-20.17,;28.57,-20.7,;27.2,-19.99,;26.83,-18.5,;27.62,-17.18,;29.17,-17.22,;29.97,-15.9,;29.23,-14.55,;30.02,-13.24,;27.69,-14.52,;26.88,-15.83,)| Show InChI InChI=1S/C15H18N4O/c1-9-18-13-8-17-15-12(6-7-16-15)14(13)19(9)10-2-4-11(20)5-3-10/h6-8,10-11,20H,2-5H2,1H3,(H,16,17)/t10-,11-	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	24	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of JAK2 kinase domain using N-terminal 5-carboxyfluorescein-tagged Val-Ala-Leu-Val-Asp-Gly-Tyr-Phe-Arg-Leu-Thr-Thr as substrate after 30 m...				J Med Chem 55: 6176-93 (2012) Article DOI: 10.1021/jm300628c BindingDB Entry DOI: 10.7270/Q25Q4X6S
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50393746 (CHEMBL2159209) Show SMILES Cc1nc2cnc3[nH]ccc3c2n1[C@H]1CC[C@H](O)CC1 |r,wU:16.19,wD:13.15,(24.47,-17.1,;25.29,-18.4,;24.72,-19.83,;25.91,-20.81,;25.96,-22.35,;27.33,-23.07,;28.63,-22.24,;30.11,-22.66,;30.96,-21.38,;30.01,-20.17,;28.57,-20.7,;27.2,-19.99,;26.83,-18.5,;27.62,-17.18,;29.17,-17.22,;29.97,-15.9,;29.23,-14.55,;30.02,-13.24,;27.69,-14.52,;26.88,-15.83,)| Show InChI InChI=1S/C15H18N4O/c1-9-18-13-8-17-15-12(6-7-16-15)14(13)19(9)10-2-4-11(20)5-3-10/h6-8,10-11,20H,2-5H2,1H3,(H,16,17)/t10-,11-	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2.20E+3	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of JAK2 in human TF1 cells assessed as inhibition of EPO-induced STAT5 phosphorylation incubated for 20 mins prior to EPO-induction measur...				J Med Chem 55: 6176-93 (2012) Article DOI: 10.1021/jm300628c BindingDB Entry DOI: 10.7270/Q25Q4X6S
					More data for this Ligand-Target Pair