Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase JAK3' and Ligand = 'BDBM141469'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM141469 (US8921368, 177) Show SMILES Cc1cccc(C)c1-c1cc2c(NC3C4CC5CC3CC(O)(C5)C4)c(cnn2c1)C(N)=O |TLB:21:20:13:15.16.17,12:13:15:20.22.23,12:13:20.19.23:15.16.17,THB:22:20:13:15.16.17,22:16:13:20.19.23,19:20:15:13.18.17,19:18:15:20.22.23,(-3.08,-.03,;-3.85,-1.36,;-5.39,-1.36,;-6.16,-2.7,;-5.39,-4.03,;-3.85,-4.03,;-3.08,-5.36,;-3.08,-2.7,;-1.54,-2.7,;-.64,-1.45,;.83,-1.93,;2.16,-1.16,;2.16,.38,;.83,1.15,;-.01,3.05,;-.01,4.59,;-1.34,5.36,;-.58,4.2,;-.57,1.8,;-1.77,1.13,;-2.67,3.05,;-4,2.28,;-2.67,4.59,;-1.34,2.28,;3.49,-1.93,;3.49,-3.47,;2.16,-4.24,;.83,-3.47,;-.64,-3.94,;4.83,-1.16,;6.16,-1.93,;4.83,.38,)| Show InChI InChI=1S/C26H30N4O2/c1-14-4-3-5-15(2)22(14)19-8-21-24(20(25(27)31)12-28-30(21)13-19)29-23-17-6-16-7-18(23)11-26(32,9-16)10-17/h3-5,8,12-13,16-18,23,29,32H,6-7,9-11H2,1-2H3,(H2,27,31)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	524	n/a	n/a	n/a	n/a	8.0	25
Bristol-Myers Squibb Company US Patent					Assay Description Kinase reactions consisted of 5 ng of JAK3 enzyme, 30 uM CSKtide substrate, 0.2 uCi gamma-33P ATP, 8 uM ATP in 30 ul kinase buffer (50 mM Hepes, pH ...				US Patent US8921368 (2014) BindingDB Entry DOI: 10.7270/Q2HH6HS7
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