Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase JAK3' and Ligand = 'BDBM141491'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM141491 (US8921368, 316) Show SMILES C[C@@]1(O)CC[C@@H](CC1)Nc1c(cnn2cc(cc12)-c1cncnc1N)C(N)=O |r,wU:5.8,1.1,wD:1.0,(-2.61,4.7,;-1.84,3.36,;-3.38,3.36,;-1.84,1.82,;-.51,1.05,;.83,1.82,;.83,3.36,;-.51,4.13,;2.16,1.05,;2.16,-.49,;3.49,-1.26,;3.49,-2.8,;2.16,-3.57,;.83,-2.8,;-.64,-3.27,;-1.54,-2.03,;-.64,-.78,;.83,-1.26,;-3.08,-2.03,;-3.85,-.69,;-5.39,-.69,;-6.16,-2.03,;-5.39,-3.36,;-3.85,-3.36,;-3.08,-4.7,;4.83,-.49,;6.16,-1.26,;4.83,1.05,)| Show InChI InChI=1S/C19H23N7O2/c1-19(28)4-2-12(3-5-19)25-16-14(18(21)27)8-24-26-9-11(6-15(16)26)13-7-22-10-23-17(13)20/h6-10,12,25,28H,2-5H2,1H3,(H2,21,27)(H2,20,22,23)/t12-,19+	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	8.0	25
Bristol-Myers Squibb Company US Patent					Assay Description Kinase reactions consisted of 5 ng of JAK3 enzyme, 30 uM CSKtide substrate, 0.2 uCi gamma-33P ATP, 8 uM ATP in 30 ul kinase buffer (50 mM Hepes, pH ...				US Patent US8921368 (2014) BindingDB Entry DOI: 10.7270/Q2HH6HS7
					More data for this Ligand-Target Pair