Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase JAK3' and Ligand = 'BDBM153206'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM153206 (US8993756, 5-41) Show SMILES CCOC(=O)c1c[nH]c2ncnc(-c3cccc(NC(=O)C(=C)CN4CCOCC4)c3)c12 Show InChI InChI=1S/C23H25N5O4/c1-3-32-23(30)18-12-24-21-19(18)20(25-14-26-21)16-5-4-6-17(11-16)27-22(29)15(2)13-28-7-9-31-10-8-28/h4-6,11-12,14H,2-3,7-10,13H2,1H3,(H,27,29)(H,24,25,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.660	n/a	n/a	n/a	n/a	n/a	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The ability of compounds to inhibit the activity of JAKl, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...				US Patent US8993756 (2015) BindingDB Entry DOI: 10.7270/Q2VQ31DJ
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