Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase JAK3' and Ligand = 'BDBM153214'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM153214 (US8993756, 13-1) Show SMILES CCOC(=O)c1c[nH]c2ncnc(-c3cccc(NC(=O)C(=C)CNS(C)(=O)=O)c3)c12 Show InChI InChI=1S/C20H21N5O5S/c1-4-30-20(27)15-10-21-18-16(15)17(22-11-23-18)13-6-5-7-14(8-13)25-19(26)12(2)9-24-31(3,28)29/h5-8,10-11,24H,2,4,9H2,1,3H3,(H,25,26)(H,21,22,23)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.0520	n/a	n/a	n/a	n/a	n/a	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The ability of compounds to inhibit the activity of JAKl, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...				US Patent US8993756 (2015) BindingDB Entry DOI: 10.7270/Q2VQ31DJ
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