Found 4 hits Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase JAK3' and Ligand = 'BDBM50121209' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50121209
(CHEMBL3622376)Show InChI InChI=1S/C11H10N6O/c1-2-12-11-8(1)10(13-6-14-11)9-4-17(16-15-9)3-7-5-18-7/h1-2,4,6-7H,3,5H2,(H,12,13,14) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University
Curated by ChEMBL
| Assay Description
Inhibition of JAK3 (unknown origin) after 20 mins by radiometric analysis in presence of [gamma33P]-ATP |
J Med Chem 58: 7611-33 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00229
BindingDB Entry DOI: 10.7270/Q2QZ2CSD |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50121209
(CHEMBL3622376)Show InChI InChI=1S/C11H10N6O/c1-2-12-11-8(1)10(13-6-14-11)9-4-17(16-15-9)3-7-5-18-7/h1-2,4,6-7H,3,5H2,(H,12,13,14) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
Eberhard Karls University T£bingen
Curated by ChEMBL
| Assay Description
Inhibition of JAK3 (unknown origin) |
J Med Chem 62: 5673-5724 (2019)
Article DOI: 10.1021/acs.jmedchem.8b01153
BindingDB Entry DOI: 10.7270/Q2959MWN |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50121209
(CHEMBL3622376)Show InChI InChI=1S/C11H10N6O/c1-2-12-11-8(1)10(13-6-14-11)9-4-17(16-15-9)3-7-5-18-7/h1-2,4,6-7H,3,5H2,(H,12,13,14) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University
Curated by ChEMBL
| Assay Description
Inhibition of human JAK3 using GGEEEEYFELVKKKK substrate preincubated for 20 mis followed by addition of ATP and measured after 120 mins in presence ... |
J Med Chem 62: 9375-9414 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00359
BindingDB Entry DOI: 10.7270/Q2BR8WFX |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50121209
(CHEMBL3622376)Show InChI InChI=1S/C11H10N6O/c1-2-12-11-8(1)10(13-6-14-11)9-4-17(16-15-9)3-7-5-18-7/h1-2,4,6-7H,3,5H2,(H,12,13,14) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
Eberhard-Karls-University Tuebingen
Curated by ChEMBL
| Assay Description
Inhibition of JAK3 (unknown origin) |
Bioorg Med Chem Lett 27: 4229-4237 (2017)
Article DOI: 10.1016/j.bmcl.2017.07.079
BindingDB Entry DOI: 10.7270/Q27P91Z2 |
More data for this
Ligand-Target Pair | |
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