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Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase JAK3' and Ligand = 'BDBM50361177'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))		BDBM50361177
PNG
(CHEMBL4160840)
Show SMILES ONC(=O)c1ccc(cc1)-c1ccnc(Nc2ccc(cc2)N2CCOCC2)n1
Show InChI InChI=1S/C21H21N5O3/c27-20(25-28)16-3-1-15(2-4-16)19-9-10-22-21(24-19)23-17-5-7-18(8-6-17)26-11-13-29-14-12-26/h1-10,28H,11-14H2,(H,25,27)(H,22,23,24)
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Second Military Medical University

Curated by ChEMBL


Assay Description
Inhibition of JAK3 (unknown origin) using FAM-labeled peptide as substrate preincubated for 10 mins followed by substrate addition and measured after...

J Med Chem 61: 6056-6074 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00393
BindingDB Entry DOI: 10.7270/Q2RN3BDN
More data for this
Ligand-Target Pair