Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase JAK3 [781-1124]' and Ligand = 'BDBM228712'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK3 [781-1124] (Homo sapiens (Human))	BDBM228712 (US10369153, Compound 48 | US9346810, 48) Show SMILES CCS(=O)(=O)N(C)[C@@H]1CCN(C1)c1ncnc2[nH]ccc12 Show InChI InChI=1S/C13H19N5O2S/c1-3-21(19,20)17(2)10-5-7-18(8-10)13-11-4-6-14-12(11)15-9-16-13/h4,6,9-10H,3,5,7-8H2,1-2H3,(H,14,15,16)/t10-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.550	n/a	n/a	n/a	n/a	n/a	25
HUTCHISON MEDIPHARMA LIMITED US Patent					Assay Description JAK1/2/3 kinase assay are performed in vitro using Kit-Tyr 6 Peptide (Invitrogen, Cat. No. PV4122). TYK2 kinase assay are performed in vitro using Z'...				US Patent US9346810 (2016) BindingDB Entry DOI: 10.7270/Q2XG9Q0X
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