Compile Data Set for Download or QSAR

Found 3 hits Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase Lck' and Ligand = 'BDBM340116'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340116 ((S,E)-4-(8-amino-3-(1-(4- methoxybut-2-enoyl)piper...) Show SMILES CCCc1ccnc(NC(=O)c2ccc(cc2F)-c2nc([C@@H]3CCCCN3C(=O)\C=C\COC)n3ccnc(N)c23)c1 |r| Show InChI InChI=1S/C31H34FN7O3/c1-3-7-20-12-13-34-25(18-20)36-31(41)22-11-10-21(19-23(22)32)27-28-29(33)35-14-16-39(28)30(37-27)24-8-4-5-15-38(24)26(40)9-6-17-42-2/h6,9-14,16,18-19,24H,3-5,7-8,15,17H2,1-2H3,(H2,33,35)(H,34,36,41)/b9-6+/t24-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...				US Patent US9758524 (2017) BindingDB Entry DOI: 10.7270/Q2GX4DPQ
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340116 ((S,E)-4-(8-amino-3-(1-(4- methoxybut-2-enoyl)piper...) Show SMILES CCCc1ccnc(NC(=O)c2ccc(cc2F)-c2nc([C@@H]3CCCCN3C(=O)\C=C\COC)n3ccnc(N)c23)c1 |r| Show InChI InChI=1S/C31H34FN7O3/c1-3-7-20-12-13-34-25(18-20)36-31(41)22-11-10-21(19-23(22)32)27-28-29(33)35-14-16-39(28)30(37-27)24-8-4-5-15-38(24)26(40)9-6-17-42-2/h6,9-14,16,18-19,24H,3-5,7-8,15,17H2,1-2H3,(H2,33,35)(H,34,36,41)/b9-6+/t24-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Merck Sharp & Dohme B.V. US Patent					Assay Description Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...				US Patent US10934296 (2021) BindingDB Entry DOI: 10.7270/Q27947T2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM340116 ((S,E)-4-(8-amino-3-(1-(4- methoxybut-2-enoyl)piper...) Show SMILES CCCc1ccnc(NC(=O)c2ccc(cc2F)-c2nc([C@@H]3CCCCN3C(=O)\C=C\COC)n3ccnc(N)c23)c1 |r| Show InChI InChI=1S/C31H34FN7O3/c1-3-7-20-12-13-34-25(18-20)36-31(41)22-11-10-21(19-23(22)32)27-28-29(33)35-14-16-39(28)30(37-27)24-8-4-5-15-38(24)26(40)9-6-17-42-2/h6,9-14,16,18-19,24H,3-5,7-8,15,17H2,1-2H3,(H2,33,35)(H,34,36,41)/b9-6+/t24-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Merck Research Laboratories					Assay Description Lck enzyme (Millipore catalog #14-442), is diluted to 0.4 U/mL in KR buffer (10 mM Tris-HCl, 10 mM MgCl2, 0.01% Tween-20, 0.05% NaN3, 1 mM DTT, 2 mM ...				J Med Chem 48: 6169-73 (2005) BindingDB Entry DOI: 10.7270/Q20R9RQ4
					More data for this Ligand-Target Pair