Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase Lyn' and Ligand = 'BDBM264378'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase Lyn (Homo sapiens (Human))	BDBM264378 (US9714247, 99) Show SMILES CCN(CC)CCOc1ccc(Nc2cc3n(CC)c(=O)c(cc3cn2)-c2ccc(F)cc2C)nc1 Show InChI InChI=1S/C28H32FN5O2/c1-5-33(6-2)12-13-36-22-9-11-26(31-18-22)32-27-16-25-20(17-30-27)15-24(28(35)34(25)7-3)23-10-8-21(29)14-19(23)4/h8-11,14-18H,5-7,12-13H2,1-4H3,(H,30,31,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Tolero Pharmaceuticals, Inc.; Mannkind Corporation US Patent					Assay Description A concentration of a drug that reduces the observed activity of an enzyme by 50%. An IC50 is not a true affinity constant and the specific value dete...				US Patent US9714247 (2017) BindingDB Entry DOI: 10.7270/Q2BR8V6C
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