Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase SYK' and Ligand = 'BDBM127940'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM127940 (US8796310, 1C) Show SMILES Cc1cc(Nc2cc(ccn2)N2CCN(CCN)CC2)nc(c1)-c1cnc(s1)C1(O)CCCc2cc(ccc12)C(O)=O Show InChI InChI=1S/C31H35N7O3S/c1-20-15-25(26-19-34-30(42-26)31(41)7-2-3-21-17-22(29(39)40)4-5-24(21)31)35-28(16-20)36-27-18-23(6-9-33-27)38-13-11-37(10-8-32)12-14-38/h4-6,9,15-19,41H,2-3,7-8,10-14,32H2,1H3,(H,39,40)(H,33,35,36)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<0.5	n/a	n/a	n/a	n/a	7.5	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Cama Bio...				US Patent US8796310 (2014) BindingDB Entry DOI: 10.7270/Q29W0D61
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