Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase SYK' and Ligand = 'BDBM127965'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM127965 (US8796310, 12A) Show SMILES Cc1cc(Nc2cc(cc[nH+]2)C(F)(F)F)nc(-c2cnc(s2)[C@@]2(O)CCCc3cc(ccc23)C(O)=O)c1Br Show InChI InChI=1S/C26H20BrF3N4O3S/c1-13-9-20(33-19-11-16(6-8-31-19)26(28,29)30)34-22(21(13)27)18-12-32-24(38-18)25(37)7-2-3-14-10-15(23(35)36)4-5-17(14)25/h4-6,8-12,37H,2-3,7H2,1H3,(H,35,36)(H,31,33,34)/p+1/t25-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<0.5	n/a	n/a	n/a	n/a	7.5	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Cama Bio...				US Patent US8796310 (2014) BindingDB Entry DOI: 10.7270/Q29W0D61
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