Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase SYK' and Ligand = 'BDBM127989'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM127989 (US8796310, 19) Show SMILES COc1c2CCCC(O)(c3ncc(s3)-c3cc(C)cc(Nc4cc(ccn4)C(F)(F)F)n3)c2ccc1C(O)=O Show InChI InChI=1S/C27H23F3N4O4S/c1-14-10-19(33-22(11-14)34-21-12-15(7-9-31-21)27(28,29)30)20-13-32-25(39-20)26(37)8-3-4-16-18(26)6-5-17(24(35)36)23(16)38-2/h5-7,9-13,37H,3-4,8H2,1-2H3,(H,35,36)(H,31,33,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<0.5	n/a	n/a	n/a	n/a	7.5	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Cama Bio...				US Patent US8796310 (2014) BindingDB Entry DOI: 10.7270/Q29W0D61
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