Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase SYK' and Ligand = 'BDBM140317'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM140317 (US8912173, 43) Show SMILES C[C@@H](Oc1cc(cc2ncccc12)-c1ccc(CN2CCOCC2)cc1)[C@H]1CNC(=O)C1 |r| Show InChI InChI=1S/C26H29N3O3/c1-18(22-15-26(30)28-16-22)32-25-14-21(13-24-23(25)3-2-8-27-24)20-6-4-19(5-7-20)17-29-9-11-31-12-10-29/h2-8,13-14,18,22H,9-12,15-17H2,1H3,(H,28,30)/t18-,22-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.300	n/a	n/a	n/a	n/a	7.5	-80
Boehringer Ingelheim International GmbH US Patent					Assay Description Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...				US Patent US8912173 (2014) BindingDB Entry DOI: 10.7270/Q2TX3D3T
					More data for this Ligand-Target Pair