Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase SYK' and Ligand = 'BDBM140347'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM140347 (US8912173, 72) Show SMILES C[C@@H](Oc1cc(cc2ncccc12)-c1ccc(OC2CCOCC2)nc1)[C@H]1CNC(=O)C1 |r| Show InChI InChI=1S/C25H27N3O4/c1-16(19-13-24(29)27-15-19)31-23-12-18(11-22-21(23)3-2-8-26-22)17-4-5-25(28-14-17)32-20-6-9-30-10-7-20/h2-5,8,11-12,14,16,19-20H,6-7,9-10,13,15H2,1H3,(H,27,29)/t16-,19-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.30	n/a	n/a	n/a	n/a	7.5	-80
Boehringer Ingelheim International GmbH US Patent					Assay Description Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...				US Patent US8912173 (2014) BindingDB Entry DOI: 10.7270/Q2TX3D3T
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