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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase SYK' and Ligand = 'BDBM172932'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM172932
PNG
(US9096579, 34)
Show SMILES CN1C(=O)COCC11CCN(CC1)C(=O)c1cc2cc(Nc3nccc(n3)-c3cn(C)cn3)cc(C)c2[nH]1
Show InChI InChI=1S/C27H30N8O3/c1-17-10-19(30-26-28-7-4-20(32-26)22-13-33(2)16-29-22)11-18-12-21(31-24(17)18)25(37)35-8-5-27(6-9-35)15-38-14-23(36)34(27)3/h4,7,10-13,16,31H,5-6,8-9,14-15H2,1-3H3,(H,28,30,32)
PDB
MMDB

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KEGG

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a 0.600n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair