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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase SYK' and Ligand = 'BDBM173039'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM173039
PNG
(US9096579, 141)
Show SMILES Cc1cc(Nc2nccc(n2)-c2cn(C)cn2)cc2cc([nH]c12)C(=O)NC[C@H]1CCCO1 |r|
Show InChI InChI=1/C23H25N7O2/c1-14-8-16(27-23-24-6-5-18(29-23)20-12-30(2)13-26-20)9-15-10-19(28-21(14)15)22(31)25-11-17-4-3-7-32-17/h5-6,8-10,12-13,17,28H,3-4,7,11H2,1-2H3,(H,25,31)(H,24,27,29)/t17-/s2
PDB
MMDB

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US Patent
n/an/a 3.70n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US9096579 (2015)


BindingDB Entry DOI: 10.7270/Q2F76B9H
More data for this
Ligand-Target Pair