Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase SYK' and Ligand = 'BDBM205332'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM205332 (US9249125, 85) Show SMILES CC(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc(Nc4ccc5[nH]ncc5c4)n3)c3ccccc23)n(n1)-c1ccc(=O)n(CCO)c1 Show InChI InChI=1S/C35H32N10O4/c1-21(2)29-18-31(45(43-29)24-8-12-33(47)44(20-24)15-16-46)40-35(48)39-28-10-11-30(26-6-4-3-5-25(26)28)49-32-13-14-36-34(41-32)38-23-7-9-27-22(17-23)19-37-42-27/h3-14,17-21,46H,15-16H2,1-2H3,(H,37,42)(H,36,38,41)(H2,39,40,48)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED US Patent					Assay Description The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...				US Patent US9249125 (2016) BindingDB Entry DOI: 10.7270/Q2CN72QG
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