Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase SYK' and Ligand = 'BDBM212230'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM212230 (US9290490, 2-1) Show SMILES Cc1cc(Nc2nccc(n2)C(F)(F)F)cc(c1)-c1cnc(s1)C(C)(O)C1CCC(CC1)C(O)=O |(1.74,-8.38,;.41,-7.61,;-.92,-8.38,;-2.26,-7.61,;-3.59,-8.38,;-4.93,-7.61,;-6.26,-8.38,;-7.59,-7.61,;-7.59,-6.07,;-6.26,-5.24,;-4.93,-6.07,;-6.26,-3.7,;-6.26,-2.16,;-4.72,-3.7,;-7.8,-3.7,;-2.26,-6.07,;-.92,-5.3,;.41,-6.07,;-.92,-3.76,;-2.17,-2.85,;-1.69,-1.39,;-.15,-1.39,;.32,-2.85,;.62,-.06,;1.39,1.28,;-.15,1.28,;2.16,-.06,;2.93,-1.39,;4.47,-1.39,;5.29,-.06,;4.47,1.28,;2.93,1.28,;6.83,-.06,;7.6,1.28,;7.6,-1.39,)| Show InChI InChI=1S/C24H25F3N4O3S/c1-13-9-15(11-17(10-13)30-22-28-8-7-19(31-22)24(25,26)27)18-12-29-21(35-18)23(2,34)16-5-3-14(4-6-16)20(32)33/h7-12,14,16,34H,3-6H2,1-2H3,(H,32,33)(H,28,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.5	n/a	n/a	n/a	n/a	7.5	25
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSyk fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-Syk (Carna Bi...				US Patent US9290490 (2016) BindingDB Entry DOI: 10.7270/Q2Z0370B
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