Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase SYK' and Ligand = 'BDBM301995'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM301995 (US9598405, 1.3) Show SMILES COC(=O)[C@H]1CC[C@@](O)(CC1(C)C)c1ncc(s1)-c1cc(C)cc(Nc2cc(ccn2)C2CC2)n1 Show InChI InChI=1S/C27H32N4O3S/c1-16-11-20(30-23(12-16)31-22-13-18(8-10-28-22)17-5-6-17)21-14-29-25(35-21)27(33)9-7-19(24(32)34-4)26(2,3)15-27/h8,10-14,17,19,33H,5-7,9,15H2,1-4H3,(H,28,30,31)/t19-,27-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.31	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...				US Patent US9598405 (2017) BindingDB Entry DOI: 10.7270/Q2BR8V7T
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