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Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase SYK' and Ligand = 'BDBM50400038'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM50400038
PNG
(CHEMBL2177732 | US9169259, I-4)
Show SMILES C1CCN(C1)c1cccc(Nc2cc(nn3ccnc23)-c2ccccc2)n1
Show InChI InChI=1S/C21H20N6/c1-2-7-16(8-3-1)17-15-18(21-22-11-14-27(21)25-17)23-19-9-6-10-20(24-19)26-12-4-5-13-26/h1-3,6-11,14-15H,4-5,12-13H2,(H,23,24)
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Article
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n/an/a 351n/an/an/an/an/an/a



Hoffmann-La Roche Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant spleen tyrosine kinase (360 to 635 amino acid residues) after 10 mins by scintillation counting analysis

J Med Chem 55: 10414-23 (2012)


Article DOI: 10.1021/jm301367c
BindingDB Entry DOI: 10.7270/Q2057H23
More data for this
Ligand-Target Pair