Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tyrosine-protein kinase TXK (Homo sapiens (Human)) | BDBM50357312 (IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Citation and Details Article DOI: 10.1016/j.ejmech.2021.114009 BindingDB Entry DOI: 10.7270/Q2ZK5MN1 | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase TXK (Homo sapiens (Human)) | BDBM50357312 (IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of recombinant human N-terminal GST-tagged TXK (260 to 527 residues) expressed in baculovirus expression system using tyrosine-6 peptide a... | Citation and Details Article DOI: 10.1016/j.bmcl.2020.127261 BindingDB Entry DOI: 10.7270/Q2TB1BM3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase TXK (Homo sapiens (Human)) | BDBM50357312 (IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 2.90 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibition of human TXK using poly[Glu:Tyr] (4:1) as substrate preincubated for 60 mins followed by [gamma-33P]-ATP addition and measured after 120 m... | J Med Chem 62: 7923-7940 (2019) Article DOI: 10.1021/acs.jmedchem.9b00687 BindingDB Entry DOI: 10.7270/Q2RJ4NXF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase TXK (Homo sapiens (Human)) | BDBM50357312 (IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 2.90 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibition of human TXK using poly[Glu:Tyr] (4:1) as substrate preincubated for 60 mins followed by [gamma-33P]-ATP addition and measured after 120 m... | J Med Chem 62: 7923-7940 (2019) Article DOI: 10.1021/acs.jmedchem.9b00687 BindingDB Entry DOI: 10.7270/Q2RJ4NXF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase TXK (Homo sapiens (Human)) | BDBM50357312 (IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University Curated by ChEMBL | Assay Description Inhibition of recombinant human TXK using Poly(Glu, Tyr) 4:1 as substrate after 1 hr by ELISA | J Med Chem 61: 4608-4627 (2018) Article DOI: 10.1021/acs.jmedchem.8b00441 BindingDB Entry DOI: 10.7270/Q2B85BRC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase TXK (Homo sapiens (Human)) | BDBM50357312 (IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 0.620 | n/a | n/a | n/a | n/a | n/a |
TBA | Citation and Details Article DOI: 10.1016/j.bmcl.2022.128549 BindingDB Entry DOI: 10.7270/Q2C251FV | ||||||||||||
More data for this Ligand-Target Pair |