Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase ZAP-70' and Ligand = 'BDBM26425'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase ZAP-70 (Homo sapiens (Human))	BDBM26425 (imidazo[1,2-c]pyrimidine-8-carboxamide, 20 | tert-...) Show SMILES COc1cc(Nc2nc(NCc3ccc(CC(=O)OC(C)(C)C)cc3)n3ccnc3c2C(N)=O)cc(OC)c1 Show InChI InChI=1S/C28H32N6O5/c1-28(2,3)39-22(35)12-17-6-8-18(9-7-17)16-31-27-33-25(23(24(29)36)26-30-10-11-34(26)27)32-19-13-20(37-4)15-21(14-19)38-5/h6-11,13-15,32H,12,16H2,1-5H3,(H2,29,36)(H,31,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.20E+3	n/a	n/a	n/a	n/a	7.6	30
Kissei Pharmaceutical Company					Assay Description A coupled spectrophotometric assay was used wherein ADP generated by ZAP-70 kinase was converted to ATP by pyruvate kinase (PK), with concomitant pro...				Bioorg Med Chem 17: 284-94 (2009) Article DOI: 10.1016/j.bmc.2008.10.070 BindingDB Entry DOI: 10.7270/Q2FQ9TXB
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