Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosyl-DNA phosphodiesterase 2' and Ligand = 'BDBM437705'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosyl-DNA phosphodiesterase 2 (Homo sapiens (Human))	BDBM437705 (US10617706, Example 139) Show SMILES Oc1cccc(c1)N1C2NC(=O)N(C(=O)C2=Cc2ccc(cc12)C#N)c1ccc(Cl)c(Cl)c1 |c:17| Show InChI InChI=1S/C24H14Cl2N4O3/c25-19-7-6-16(11-20(19)26)30-23(32)18-9-14-5-4-13(12-27)8-21(14)29(22(18)28-24(30)33)15-2-1-3-17(31)10-15/h1-11,22,31H,(H,28,33)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	13.6	n/a	n/a	n/a	n/a	n/a	n/a
REGENTS OF THE UNIVERSITY OF MINNESOTA; THE USA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES US Patent					Assay Description The enzymatic activity of TDP2 was measured with a SUMO hTDP2cat fluorescence-based biochemical assay. To a black 384-well plate, 10 μL of compo...				US Patent US10617706 (2020) BindingDB Entry DOI: 10.7270/Q20C4ZT8
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