BindingDB PrimarySearch

Found 2 hits Enz. Inhib. hit(s) with Target = 'UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase' and Ligand = 'BDBM50137778'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase (Streptococcus pneumoniae (Firmicutes))	BDBM50137778 (2-Chloro-N-(3-cyano-5,6-dihydro-4H-cyclopenta[b]th...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Similars	DrugBank MMDB PDB PubMed	n/a	n/a	8.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Antibacterial activity against UDP-MurNAc-pentapeptide synthetase from Streptococcus pneumoniae.				Bioorg Med Chem Lett 14: 267-70 (2003) BindingDB Entry DOI: 10.7270/Q2R49Q55
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase (Streptococcus pneumoniae (Firmicutes))	BDBM50137778 (2-Chloro-N-(3-cyano-5,6-dihydro-4H-cyclopenta[b]th...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Similars	DrugBank MMDB PDB Article PubMed	n/a	n/a	8.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description Inhibition of D-Ala-D-Ala adding enzyme (MurF) from Streptococcus pneumoniase.				Chem Biol Drug Des 67: 58-65 (2006) Article DOI: 10.1111/j.1747-0285.2005.00317.x BindingDB Entry DOI: 10.7270/Q2GF0S0Z
Abbott Laboratories					More data for this Ligand-Target Pair				3D Structure (crystal)