Found 3 hits Enz. Inhib. hit(s) with Target = 'Vascular endothelial growth factor receptor 2' and Ligand = 'BDBM4636' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM4636
(4-anilinocinnoline deriv. 19 | CHEMBL150825 | N-(4...)Show InChI InChI=1S/C18H17ClFN3O3/c1-24-5-6-26-18-9-15-12(8-17(18)25-2)16(10-21-23-15)22-14-4-3-11(19)7-13(14)20/h3-4,7-10H,5-6H2,1-2H3,(H,22,23) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Jiaotong University
Curated by ChEMBL
| Assay Description Inhibition of KDR |
Bioorg Med Chem Lett 17: 2126-33 (2007)
Article DOI: 10.1016/j.bmcl.2007.01.089 BindingDB Entry DOI: 10.7270/Q2S1839D |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM4636
(4-anilinocinnoline deriv. 19 | CHEMBL150825 | N-(4...)Show InChI InChI=1S/C18H17ClFN3O3/c1-24-5-6-26-18-9-15-12(8-17(18)25-2)16(10-21-23-15)22-14-4-3-11(19)7-13(14)20/h3-4,7-10H,5-6H2,1-2H3,(H,22,23) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Jiaotong University
Curated by ChEMBL
| Assay Description Inhibition of KDR |
Bioorg Med Chem Lett 17: 2126-33 (2007)
Article DOI: 10.1016/j.bmcl.2007.01.089 BindingDB Entry DOI: 10.7270/Q2S1839D |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM4636
(4-anilinocinnoline deriv. 19 | CHEMBL150825 | N-(4...)Show InChI InChI=1S/C18H17ClFN3O3/c1-24-5-6-26-18-9-15-12(8-17(18)25-2)16(10-21-23-15)22-14-4-3-11(19)7-13(14)20/h3-4,7-10H,5-6H2,1-2H3,(H,22,23) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | 25 |
AstraZeneca
| Assay Description An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room... |
J Med Chem 42: 5369-89 (1999)
Article DOI: 10.1021/jm990345w BindingDB Entry DOI: 10.7270/Q2F47MBM |
More data for this Ligand-Target Pair | |