Found 6 hits Enz. Inhib. hit(s) with Target = 'Vascular endothelial growth factor receptor 2' and Ligand = 'BDBM8813' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM8813
(3-(4-{4-amino-6-methylthieno[2,3-d]pyrimidin-5-yl}...)Show SMILES Cc1sc2ncnc(N)c2c1-c1ccc(NC(=O)Nc2cccc(C)c2)cc1 Show InChI InChI=1S/C21H19N5OS/c1-12-4-3-5-16(10-12)26-21(27)25-15-8-6-14(7-9-15)17-13(2)28-20-18(17)19(22)23-11-24-20/h3-11H,1-2H3,(H2,22,23,24)(H2,25,26,27) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Jiaotong University
Curated by ChEMBL
| Assay Description Inhibition of KDR |
Bioorg Med Chem Lett 17: 2126-33 (2007)
Article DOI: 10.1016/j.bmcl.2007.01.089 BindingDB Entry DOI: 10.7270/Q2S1839D |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM8813
(3-(4-{4-amino-6-methylthieno[2,3-d]pyrimidin-5-yl}...)Show SMILES Cc1sc2ncnc(N)c2c1-c1ccc(NC(=O)Nc2cccc(C)c2)cc1 Show InChI InChI=1S/C21H19N5OS/c1-12-4-3-5-16(10-12)26-21(27)25-15-8-6-14(7-9-15)17-13(2)28-20-18(17)19(22)23-11-24-20/h3-11H,1-2H3,(H2,22,23,24)(H2,25,26,27) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Jiaotong University
| Assay Description Inhibition assay using KDR. |
Chem Biol Drug Des 69: 204-11 (2007)
Article DOI: 10.1111/j.1747-0285.2007.00488.x BindingDB Entry DOI: 10.7270/Q2ZG6QQH |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM8813
(3-(4-{4-amino-6-methylthieno[2,3-d]pyrimidin-5-yl}...)Show SMILES Cc1sc2ncnc(N)c2c1-c1ccc(NC(=O)Nc2cccc(C)c2)cc1 Show InChI InChI=1S/C21H19N5OS/c1-12-4-3-5-16(10-12)26-21(27)25-15-8-6-14(7-9-15)17-13(2)28-20-18(17)19(22)23-11-24-20/h3-11H,1-2H3,(H2,22,23,24)(H2,25,26,27) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Abbott Laboratories
| Assay Description The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor... |
J Med Chem 48: 6066-83 (2005)
Article DOI: 10.1021/jm050458h BindingDB Entry DOI: 10.7270/Q2WD3XSF |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM8813
(3-(4-{4-amino-6-methylthieno[2,3-d]pyrimidin-5-yl}...)Show SMILES Cc1sc2ncnc(N)c2c1-c1ccc(NC(=O)Nc2cccc(C)c2)cc1 Show InChI InChI=1S/C21H19N5OS/c1-12-4-3-5-16(10-12)26-21(27)25-15-8-6-14(7-9-15)17-13(2)28-20-18(17)19(22)23-11-24-20/h3-11H,1-2H3,(H2,22,23,24)(H2,25,26,27) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Research Foundation
Curated by ChEMBL
| Assay Description Inhibition of VEGFR-2 kinase |
Nat Chem Biol 2: 358-64 (2006)
Article DOI: 10.1038/nchembio799 BindingDB Entry DOI: 10.7270/Q2CC10WV |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM8813
(3-(4-{4-amino-6-methylthieno[2,3-d]pyrimidin-5-yl}...)Show SMILES Cc1sc2ncnc(N)c2c1-c1ccc(NC(=O)Nc2cccc(C)c2)cc1 Show InChI InChI=1S/C21H19N5OS/c1-12-4-3-5-16(10-12)26-21(27)25-15-8-6-14(7-9-15)17-13(2)28-20-18(17)19(22)23-11-24-20/h3-11H,1-2H3,(H2,22,23,24)(H2,25,26,27) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Jiaotong University
Curated by ChEMBL
| Assay Description Inhibition of KDR |
Bioorg Med Chem Lett 17: 2126-33 (2007)
Article DOI: 10.1016/j.bmcl.2007.01.089 BindingDB Entry DOI: 10.7270/Q2S1839D |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM8813
(3-(4-{4-amino-6-methylthieno[2,3-d]pyrimidin-5-yl}...)Show SMILES Cc1sc2ncnc(N)c2c1-c1ccc(NC(=O)Nc2cccc(C)c2)cc1 Show InChI InChI=1S/C21H19N5OS/c1-12-4-3-5-16(10-12)26-21(27)25-15-8-6-14(7-9-15)17-13(2)28-20-18(17)19(22)23-11-24-20/h3-11H,1-2H3,(H2,22,23,24)(H2,25,26,27) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6.03 | n/a | n/a | n/a | n/a | n/a | n/a |
Dalian University
Curated by ChEMBL
| Assay Description Inhibition of KDR |
J Mol Graph Model 26: 236-45 (2007)
Article DOI: 10.1016/j.jmgm.2006.12.001 BindingDB Entry DOI: 10.7270/Q2GQ7019 |
More data for this Ligand-Target Pair | |