BindingDB PrimarySearch

Found 7 hits Enz. Inhib. hit(s) with Target = 'Voltage-dependent L-type calcium channel subunit alpha-1S' and Ligand = 'BDBM50004704'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Voltage-dependent L-type calcium channel subunit alpha-1S (Rattus norvegicus)	BDBM50004704 ((+)-cis-Diltiazem \| (2S,3S)-5-(2-(dimethylamino)et...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article	16	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibitory constant against calcium channel receptors (CCRs)				Citation and Details Article DOI: 10.1016/S0960-894X(01)80337-1 BindingDB Entry DOI: 10.7270/Q2F47RV0
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Voltage-dependent L-type calcium channel subunit alpha-1S (Rattus norvegicus)	BDBM50004704 ((+)-cis-Diltiazem \| (2S,3S)-5-(2-(dimethylamino)et...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PDB	16	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Displacement of [3H]nitrendipine from calcium channel receptor				Citation and Details BindingDB Entry DOI: 10.7270/Q2F47RB8
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Voltage-dependent L-type calcium channel subunit alpha-1S (Rattus norvegicus)	BDBM50004704 ((+)-cis-Diltiazem \| (2S,3S)-5-(2-(dimethylamino)et...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	85	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universita degli Studi di Bologna Curated by ChEMBL					Assay Description Displacement of [3H]diltiazem from L-type calcium channel in Sprague-Dawley rat cardiac myocytes by liquid scintillation counting				J Med Chem 52: 2352-62 (2009) Article DOI: 10.1021/jm801351u BindingDB Entry DOI: 10.7270/Q2MP562C
Universita degli Studi di Bologna Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Voltage-dependent L-type calcium channel subunit alpha-1S (Homo sapiens (Human))	BDBM50004704 ((+)-cis-Diltiazem \| (2S,3S)-5-(2-(dimethylamino)et...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article	380	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Displacement of [3H]-diltiazem from L-type calcium channel of guinea pig striated muscle				Bioorg Med Chem Lett 3: 2797-2800 (1993) Article DOI: 10.1016/S0960-894X(01)80767-8 BindingDB Entry DOI: 10.7270/Q2FN164V
TBA Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Voltage-dependent L-type calcium channel subunit alpha-1S (Rattus norvegicus)	BDBM50004704 ((+)-cis-Diltiazem \| (2S,3S)-5-(2-(dimethylamino)et...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PDB	n/a	n/a	42	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Displacement of [3H]nitrendipine from calcium channel receptor				Citation and Details BindingDB Entry DOI: 10.7270/Q2F47RB8
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Voltage-dependent L-type calcium channel subunit alpha-1S (Rattus norvegicus)	BDBM50004704 ((+)-cis-Diltiazem \| (2S,3S)-5-(2-(dimethylamino)et...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article	n/a	n/a	42	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Displacement of [3H]nitrendipine from calcium channel receptors (CCRs)				Citation and Details Article DOI: 10.1016/S0960-894X(01)80337-1 BindingDB Entry DOI: 10.7270/Q2F47RV0
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Voltage-dependent L-type calcium channel subunit alpha-1S (Rattus norvegicus)	BDBM50004704 ((+)-cis-Diltiazem \| (2S,3S)-5-(2-(dimethylamino)et...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	2.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
Universita degli Studi di Bologna Curated by ChEMBL					Assay Description Inhibition of L-type calcium channel in Wistar rat tail artery smooth muscle cells assessed as blockade of barium-sensitive inward rectifying current...				J Med Chem 52: 2352-62 (2009) Article DOI: 10.1021/jm801351u BindingDB Entry DOI: 10.7270/Q2MP562C
Universita degli Studi di Bologna Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)