Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Voltage-dependent calcium channel gamma-8 subunit' and Ligand = 'BDBM288251'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM288251 (5-(2-Cyclopropyl-6-(trifluoromethyl)pyrazolo[1,5-a...) Show SMILES Cc1cc(cc2cn[nH]c12)-c1c(ccc2cc(nn12)C1CC1)C(F)(F)F Show InChI InChI=1S/C19H15F3N4/c1-10-6-12(7-13-9-23-24-17(10)13)18-15(19(20,21)22)5-4-14-8-16(11-2-3-11)25-26(14)18/h4-9,11H,2-3H2,1H3,(H,23,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0500	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H
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