Compile Data Set for Download or QSAR

Found 3 hits Enz. Inhib. hit(s) with Target = 'cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A' and Ligand = 'BDBM115431'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Rattus norvegicus (rat))	BDBM115431 (US8637500, 301 | US8637500, 454 | US8637500, 455) Show SMILES CC(=O)N1CCCC(C1)c1cccnc1Oc1ccc(Nc2ccc(C)cn2)cc1 Show InChI InChI=1S/C24H26N4O2/c1-17-7-12-23(26-15-17)27-20-8-10-21(11-9-20)30-24-22(6-3-13-25-24)19-5-4-14-28(16-19)18(2)29/h3,6-13,15,19H,4-5,14,16H2,1-2H3,(H,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.0400	n/a	n/a	n/a	n/a	n/a	25
Amgen Inc. US Patent					Assay Description An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 μL of serial diluted PDE10A (BPS Bi...				US Patent US8637500 (2014) BindingDB Entry DOI: 10.7270/Q2XP73MV
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Rattus norvegicus (rat))	BDBM115431 (US8637500, 301 | US8637500, 454 | US8637500, 455) Show SMILES CC(=O)N1CCCC(C1)c1cccnc1Oc1ccc(Nc2ccc(C)cn2)cc1 Show InChI InChI=1S/C24H26N4O2/c1-17-7-12-23(26-15-17)27-20-8-10-21(11-9-20)30-24-22(6-3-13-25-24)19-5-4-14-28(16-19)18(2)29/h3,6-13,15,19H,4-5,14,16H2,1-2H3,(H,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	25
Amgen Inc. US Patent					Assay Description An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 μL of serial diluted PDE10A (BPS Bi...				US Patent US8637500 (2014) BindingDB Entry DOI: 10.7270/Q2XP73MV
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Rattus norvegicus (rat))	BDBM115431 (US8637500, 301 | US8637500, 454 | US8637500, 455) Show SMILES CC(=O)N1CCCC(C1)c1cccnc1Oc1ccc(Nc2ccc(C)cn2)cc1 Show InChI InChI=1S/C24H26N4O2/c1-17-7-12-23(26-15-17)27-20-8-10-21(11-9-20)30-24-22(6-3-13-25-24)19-5-4-14-28(16-19)18(2)29/h3,6-13,15,19H,4-5,14,16H2,1-2H3,(H,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	25
Amgen Inc. US Patent					Assay Description An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 μL of serial diluted PDE10A (BPS Bi...				US Patent US8637500 (2014) BindingDB Entry DOI: 10.7270/Q2XP73MV
					More data for this Ligand-Target Pair