Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A' and Ligand = 'BDBM124996'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM124996 (US8772510, 15) Show SMILES Cn1nc(nc1CCNC(=O)c1c(cnn1C)C(=O)N1CCC1)-c1cccnc1 Show InChI InChI=1S/C19H22N8O2/c1-25-15(23-17(24-25)13-5-3-7-20-11-13)6-8-21-18(28)16-14(12-22-26(16)2)19(29)27-9-4-10-27/h3,5,7,11-12H,4,6,8-10H2,1-2H3,(H,21,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	207	n/a	n/a	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description PDE10 activity of the compounds of the present invention was determined using a Scintillation Proximity Assay (SPA)-based method similar to the one p...				US Patent US8772510 (2014) BindingDB Entry DOI: 10.7270/Q2MG7N67
					More data for this Ligand-Target Pair