Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A' and Ligand = 'BDBM125023'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM125023 (US8772510, 42) Show SMILES Cc1oc(nc1CCNC(=O)c1c(cnn1C)C(=O)N1CCSCC1)-c1ccccc1 Show InChI InChI=1S/C22H25N5O3S/c1-15-18(25-21(30-15)16-6-4-3-5-7-16)8-9-23-20(28)19-17(14-24-26(19)2)22(29)27-10-12-31-13-11-27/h3-7,14H,8-13H2,1-2H3,(H,23,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	260	n/a	n/a	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description PDE10 activity of the compounds of the present invention was determined using a Scintillation Proximity Assay (SPA)-based method similar to the one p...				US Patent US8772510 (2014) BindingDB Entry DOI: 10.7270/Q2MG7N67
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