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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A' and Ligand = 'BDBM125581'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM125581
PNG
(US8772316, 64)
Show SMILES CCCc1[nH]c(=O)c(Cc2cc3cc4OCOc4cc3nc2NCC)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C27H29N3O5/c1-5-7-20-18-12-23(33-4)22(32-3)11-17(18)19(27(31)30-20)9-16-8-15-10-24-25(35-14-34-24)13-21(15)29-26(16)28-6-2/h8,10-13H,5-7,9,14H2,1-4H3,(H,28,29)(H,30,31)
PDB
MMDB

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PC cid
PC sid
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US Patent
n/an/a 1.20n/an/an/an/a7.4n/a



Allergan, Inc.; Exonhit Therapeutics SA

US Patent


Assay Description
The PDE assay is based on the homogenous time-resolved fluorescence resonance energy transfer (TR-FRET) technology (LANCE from Perkin Elmer). This co...


US Patent US8772316 (2014)


BindingDB Entry DOI: 10.7270/Q2Q81BR8
More data for this
Ligand-Target Pair