Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A' and Ligand = 'BDBM144730'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM144730 (US8952037, 113) Show SMILES C1[C@@H](C[C@@H]1Oc1nccnc1C1CCOCC1)Nc1ccc2ccccc2n1 |r,wD:3.4,1.19,(-.79,-1.14,;-.39,-2.63,;-1.88,-3.03,;-2.28,-1.54,;-3.61,-.77,;-4.94,-1.54,;-4.94,-3.08,;-6.28,-3.85,;-7.61,-3.08,;-7.61,-1.54,;-6.28,-.77,;-6.28,.77,;-4.94,1.54,;-4.94,3.08,;-6.28,3.85,;-7.61,3.08,;-7.61,1.54,;.94,-3.4,;2.28,-2.63,;2.28,-1.09,;3.61,-.32,;4.94,-1.09,;6.28,-.32,;7.61,-1.09,;7.61,-2.63,;6.28,-3.4,;4.94,-2.63,;3.61,-3.4,)| Show InChI InChI=1S/C22H24N4O2/c1-2-4-19-15(3-1)5-6-20(26-19)25-17-13-18(14-17)28-22-21(23-9-10-24-22)16-7-11-27-12-8-16/h1-6,9-10,16-18H,7-8,11-14H2,(H,25,26)/t17-,18+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7.5	n/a	n/a	n/a	n/a	n/a	25
Amgen Inc. US Patent					Assay Description Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P...				US Patent US8952037 (2015) BindingDB Entry DOI: 10.7270/Q23X85CW
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