Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A' and Ligand = 'BDBM147145'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM147145 (US8957077, 1-22) Show SMILES Cc1ccc(nc1)[C@H]1C[C@@H]1COc1cc(Oc2ccc(C)nc2)n2nccc2n1 |r| Show InChI InChI=1S/C22H21N5O2/c1-14-3-6-19(24-11-14)18-9-16(18)13-28-21-10-22(27-20(26-21)7-8-25-27)29-17-5-4-15(2)23-12-17/h3-8,10-12,16,18H,9,13H2,1-2H3/t16-,18+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description In a typical experiment the PDE10 inhibitory activity of the compounds of the present invention was determined in accordance with the following exper...				US Patent US8957077 (2015) BindingDB Entry DOI: 10.7270/Q29G5KHW
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