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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A' and Ligand = 'BDBM194437'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM194437
PNG
(US9200016, 119 | US9902710, Compound 119)
Show SMILES COCc1ncc(Cc2ccc3cccc(NS(N)(=O)=O)c3n2)c2cc(OC)c(OC)cc12
Show InChI InChI=1S/C23H24N4O5S/c1-30-13-20-18-11-22(32-3)21(31-2)10-17(18)15(12-25-20)9-16-8-7-14-5-4-6-19(23(14)26-16)27-33(24,28)29/h4-8,10-12,27H,9,13H2,1-3H3,(H2,24,28,29)
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PC cid
PC sid
UniChem
US Patent
n/an/a 0.180n/an/an/an/a7.437



Allergan, Inc.; Exonhit Therapeutics, SA

US Patent


Assay Description
The phosphodiesterase assay was developed using the LANCE cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1....


US Patent US9200016 (2015)


BindingDB Entry DOI: 10.7270/Q2ZC81PH
More data for this
Ligand-Target Pair