Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A' and Ligand = 'BDBM267208'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM267208 ((1-{3-[1-(7-Chloro- quinoxalin-2-yl)-azetidin-3- y...) Show SMILES OCC1CCN(CC1)c1nccnc1C1CN(C1)c1ccc2ccc(Cl)cc2n1 Show InChI InChI=1S/C22H24ClN5O/c23-18-3-1-16-2-4-20(26-19(16)11-18)28-12-17(13-28)21-22(25-8-7-24-21)27-9-5-15(14-29)6-10-27/h1-4,7-8,11,15,17,29H,5-6,9-10,12-14H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	25
Amgen Inc. US Patent					Assay Description An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...				US Patent US9718803 (2017) BindingDB Entry DOI: 10.7270/Q2J968DN
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