Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A' and Ligand = 'BDBM317153'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM317153 (6,7-Dimethyl-2-(2-(1-methyl-3-(pyrrolidin-1-yl)-1H...) Show SMILES Cc1nc2c(O)nc(CCc3nc(nn3C)N3CCCC3)nn2c1C Show InChI InChI=1S/C16H22N8O/c1-10-11(2)24-14(17-10)15(25)18-12(20-24)6-7-13-19-16(21-22(13)3)23-8-4-5-9-23/h4-9H2,1-3H3,(H,18,20,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	225	n/a	n/a	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description The human PDE10A full length assay was performed in 96-well micro titer plates. The reaction mixture of 50 μl contained 20 mM HEPES pH=7.5/10 mM...				US Patent US9617271 (2017) BindingDB Entry DOI: 10.7270/Q2N58PFC
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