Compile Data Set for Download or QSAR

Found 3 hits Enz. Inhib. hit(s) with Target = 'cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A' and Ligand = 'BDBM329528'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM329528 (1-(5-(2-methyl-4- (((1S,2S)-2-(5- methylpyridin-2-...) Show SMILES CC(O)c1ccc(cn1)-c1cnc(C)nc1OC[C@H]1C[C@@H]1c1ccc(C)cn1 |r| Show InChI InChI=1S/C22H24N4O2/c1-13-4-6-21(24-9-13)18-8-17(18)12-28-22-19(11-23-15(3)26-22)16-5-7-20(14(2)27)25-10-16/h4-7,9-11,14,17-18,27H,8,12H2,1-3H3/t14?,17-,18+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.140	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...				US Patent US9663513 (2017) BindingDB Entry DOI: 10.7270/Q25D8TXC
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM329528 (1-(5-(2-methyl-4- (((1S,2S)-2-(5- methylpyridin-2-...) Show SMILES CC(O)c1ccc(cn1)-c1cnc(C)nc1OC[C@H]1C[C@@H]1c1ccc(C)cn1 |r| Show InChI InChI=1S/C22H24N4O2/c1-13-4-6-21(24-9-13)18-8-17(18)12-28-22-19(11-23-15(3)26-22)16-5-7-20(14(2)27)25-10-16/h4-7,9-11,14,17-18,27H,8,12H2,1-3H3/t14?,17-,18+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.240	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...				US Patent US9663513 (2017) BindingDB Entry DOI: 10.7270/Q25D8TXC
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM329528 (1-(5-(2-methyl-4- (((1S,2S)-2-(5- methylpyridin-2-...) Show SMILES CC(O)c1ccc(cn1)-c1cnc(C)nc1OC[C@H]1C[C@@H]1c1ccc(C)cn1 |r| Show InChI InChI=1S/C22H24N4O2/c1-13-4-6-21(24-9-13)18-8-17(18)12-28-22-19(11-23-15(3)26-22)16-5-7-20(14(2)27)25-10-16/h4-7,9-11,14,17-18,27H,8,12H2,1-3H3/t14?,17-,18+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.980	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...				US Patent US9663513 (2017) BindingDB Entry DOI: 10.7270/Q25D8TXC
					More data for this Ligand-Target Pair