Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A' and Ligand = 'BDBM347644'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM347644 (2-[2-[4-[1-methyl-4-(4-pyridyl)pyrazol-3-yl]phenyl...) Show SMILES Cn1cc(c(n1)-c1ccc(cc1)C#Cc1cn2ccccc2n1)-c1ccncc1 Show InChI InChI=1S/C24H17N5/c1-28-17-22(19-11-13-25-14-12-19)24(27-28)20-8-5-18(6-9-20)7-10-21-16-29-15-3-2-4-23(29)26-21/h2-6,8-9,11-17H,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
ABBVIE INC.; ABBVIE DEUTSCHLAND GMBH & CO. KG US Patent					Assay Description The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...				US Patent US9790203 (2017) BindingDB Entry DOI: 10.7270/Q2ZG6VD4
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