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Found 1 hit Enz. Inhib. hit(s) with Target = 'cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A' and Ligand = 'BDBM347657'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM347657
PNG
(2-methyl-6-[2-[4-[1-methyl-4-(3-pyridyl)pyrazol-3-...)
Show SMILES Cc1cccc(n1)C#Cc1ccc(cc1)-c1nn(C)cc1-c1cccnc1
Show InChI InChI=1S/C23H18N4/c1-17-5-3-7-21(25-17)13-10-18-8-11-19(12-9-18)23-22(16-27(2)26-23)20-6-4-14-24-15-20/h3-9,11-12,14-16H,1-2H3
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US Patent
n/an/a 375n/an/an/an/an/an/a



ABBVIE INC.; ABBVIE DEUTSCHLAND GMBH & CO. KG

US Patent


Assay Description
The PDE enzymatic reaction was carried out in assay buffer (20 mM Tris-HCl pH7.5, 10 mM MgCl2, 0.1% bovine serum albumin) containing enzyme and subst...

US Patent US9790203 (2017)


BindingDB Entry DOI: 10.7270/Q2ZG6VD4
More data for this
Ligand-Target Pair