Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A' and Ligand = 'BDBM362639'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362639 (US10562916, Compound 201 | US9834564, Compound 201) Show SMILES Cc1c(CCc2ccc3ncccc3n2)nc2c3cccnc3ccn12 Show InChI InChI=1S/C21H17N5/c1-14-17(8-6-15-7-9-19-20(24-15)5-3-12-23-19)25-21-16-4-2-11-22-18(16)10-13-26(14)21/h2-5,7,9-13H,6,8H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM362639 (US10562916, Compound 201 | US9834564, Compound 201) Show SMILES Cc1c(CCc2ccc3ncccc3n2)nc2c3cccnc3ccn12 Show InChI InChI=1S/C21H17N5/c1-14-17(8-6-15-7-9-19-20(24-15)5-3-12-23-19)25-21-16-4-2-11-22-18(16)10-13-26(14)21/h2-5,7,9-13H,6,8H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals Inc. US Patent					Assay Description The activities of the compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 e...				US Patent US9834564 (2017) BindingDB Entry DOI: 10.7270/Q2FF3VN4
					More data for this Ligand-Target Pair