Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A' and Ligand = 'BDBM364350'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM364350 (US10570156, Compound 32 | US9856274, Compound 32) Show SMILES Cc1ccc(C)n2cc(CCc3nc4c(ccc5ncccc45)n3C)nc12 Show InChI InChI=1S/C22H21N5/c1-14-6-7-15(2)27-13-16(24-22(14)27)8-11-20-25-21-17-5-4-12-23-18(17)9-10-19(21)26(20)3/h4-7,9-10,12-13H,8,11H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
SUNOVION PHARMACEUTICALS INC. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10570156 (2020) BindingDB Entry DOI: 10.7270/Q2H997MR
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM364350 (US10570156, Compound 32 | US9856274, Compound 32) Show SMILES Cc1ccc(C)n2cc(CCc3nc4c(ccc5ncccc45)n3C)nc12 Show InChI InChI=1S/C22H21N5/c1-14-6-7-15(2)27-13-16(24-22(14)27)8-11-20-25-21-17-5-4-12-23-18(17)9-10-19(21)26(20)3/h4-7,9-10,12-13H,8,11H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Rheinische Friedrich-Wilhelms-Universitat Bonn					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				J Med Chem 48: 7688-707 (2005) BindingDB Entry DOI: 10.7270/Q2Z89FPT
					More data for this Ligand-Target Pair