Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A' and Ligand = 'BDBM50085596'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Rattus norvegicus (rat))	BDBM50085596 (CHEMBL3425536) Show SMILES Cc1nc2ccncc2n2c(nnc12)-c1cc(OC(F)(F)F)ccc1Cl Show InChI InChI=1S/C16H9ClF3N5O/c1-8-14-23-24-15(25(14)13-7-21-5-4-12(13)22-8)10-6-9(2-3-11(10)17)26-16(18,19)20/h2-7H,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.91E+3	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica N.V. Curated by ChEMBL					Assay Description Inhibition of 6-His-tagged rat recombinant PDE10A expressed in Sf9 cells using [3H]cAMP incubated for 60 mins by scintillation proximity assay				ACS Med Chem Lett 6: 282-6 (2015) Article DOI: 10.1021/ml500463t BindingDB Entry DOI: 10.7270/Q2319XMJ
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