Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A' and Ligand = 'BDBM99055'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Rattus norvegicus (rat))	BDBM99055 (US8497265, 739) Show SMILES CC(C)(C)OC(=O)N1CC(C1)Oc1ncccc1[C@H]1CC[C@H](O)CC1 |r,wU:18.19,wD:21.23,(6.28,-2.85,;4.94,-3.62,;4.94,-5.16,;6.28,-4.39,;3.61,-2.85,;2.28,-3.62,;2.28,-5.16,;.94,-2.85,;-.54,-3.25,;-.94,-1.77,;.54,-1.37,;-2.28,-1,;-3.61,-1.77,;-3.61,-3.31,;-4.94,-4.08,;-6.28,-3.31,;-6.28,-1.77,;-4.94,-1,;-4.94,.54,;-6.28,1.31,;-6.28,2.85,;-4.94,3.62,;-4.94,5.16,;-3.61,2.85,;-3.61,1.31,)| Show InChI InChI=1S/C19H28N2O4/c1-19(2,3)25-18(23)21-11-15(12-21)24-17-16(5-4-10-20-17)13-6-8-14(22)9-7-13/h4-5,10,13-15,22H,6-9,11-12H2,1-3H3/t13-,14-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	15.8	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. US Patent					Assay Description Enzyme activity: An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale, Calif).				US Patent US8497265 (2013) BindingDB Entry DOI: 10.7270/Q2VD6X39
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